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[24] [95] [96] Stimulants such as amphetamine can improve performance on difficult and boring tasks and are used by some students as a study and test-taking aid

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The PVN is a set of nuclei and neural circuits that acts as a stressor, absorbing, and processing factor, which responds to a wide range of physiological stressors and plays a major role in neural regulation of endocrine and autonomic stress responses

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An animal study conducted by Koeth and colleagues found that TMAO decreases the bile acid pool size and inhibits the expressions of the key BA synthetic enzymes (Cyp7a1 and Cyp27a1) and BA transporters (Oatp1, Oatp4, Mrp2, and Ntcp) in the liver (Koeth et al., 2013)