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Erta M, Quintana A, Hidalgo J (2012) Interleukin-6, a major cytokine in the central nervous system

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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

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Brief ROS pulses support normal physiology by tuning cell-fate decisions and adaptive responses, such as aiding sperm capacitation and motility [102], priming lymphocyte activation [103], guiding stem/progenitor differentiation [104], and coordinating wound repair and angiogenesis [105]