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To overcome these limitations, we previously developed a fluorescent real-time thiol tracer (FreSHtracer) that monitors cellular levels of glutathione (GSH), which are known to be closely associated with stem cell function

JAMA 330 , 306 (2023)

By restoring this critical barrier, Larazotide prevents harmful substances from leaking into the bloodstream, reducing systemic inflammation and alleviating symptoms associated with leaky gut

For example, Astragalus polysaccharide (APS) was shown to inhibit the formation of the pre-metastatic niche in lung cancer by blocking the S1PR1/STAT3 signaling pathway, thereby preventing metastasis when used alongside standard treatment (143)