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Constitutive MECP2 knockout (KO) mice, designed to study MECP2 loss, exhibit severe neurological symptoms such as uncoordinated gait, hindlimb clasping, and irregular breathing after an initial period of normal development (111, 112)

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On the other hand, we hypothesized in this article that ten-eleven translocation inhibitors could be another class of epigenetic modifiers since they could prevent chromosomal instability through decreasing the global hypomethylation of genomic DNA

Sample Transparency Requirement The method requires that the sample be a transparent or clarified solution

Acknowledgements Is directed to the National Research Center Egypt

N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntingtons disease