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Isoniazid metabolism and hepatotoxicity
Interim phase 1 data in heavily pretreated mCRC showed 28% ORR and 94% DCR across prioritized dose levels, 43% ORR at 10 mg/kg, and median PFS 5.8 months
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NAC may be useful when: Cysteine availability may be limiting The goal is to support internal glutathione synthesis Direct glutathione is poorly tolerated A clinician has identified a relevant medical or nutritional reason NAC does not guarantee that glutathione production will increase adequately
Benefits : Reduces fatigue, enhances endurance, and supports muscle repair
