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In CKD, systemic inflammation elevates pro-inflammatory cytokines such as IL-6 and TNF-, which upregulate RANKL expression while suppressing OPG, a decoy receptor that curbs RANKL activity, thereby tipping the balance toward osteoclastogenesis (43)

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Poljsak B, uput D, Milisav I (2013) Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants, oxidative medicine and cellular longevity

10.1083/jcb.202501023 12 FanS.YanX.HuX.LiuX.ZhaoS.ZhangY.et al (2024)

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