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Transforming growth factor- (TGF-) is known to promote fibrosis and contribute to POF (Persani et al., 2011), and collagen content and fibroblast proliferation are significantly reduced, which is related to AMPK-mediated suppression of TGF- production after metformin administration (McCloskey et al., 2020)

Oral calcitriol for the treatment of persistent proteinuria in immunoglobulin a nephropathy: an uncontrolled trial

Ramirez-Zamora, A

Notably, Molidustat robustly stabilises HIF-1 and induces VEGF to levels comparable to hypoxia, presenting an opportunity for combination strategies that counterbalance HIF-driven angiogenesis

MA, SC, and DK were involved in reviewing