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(91) demonstrated that SIN significantly inhibited the production of TNF- , MCP-1, MIF, and MMP-9, downregulated CD14 and TLR4 expression, and reduced intracellular free calcium release

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McBreairty LE, Kazemi M, Chilibeck PD, Gordon JJ, Chizen DR, Zello GA

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Additionally, cocaine use in PLWH upregulates expression of activated leukocyte cell adhesion molecule in brain endothelium, promoting monocyte adhesion and transmigration across the BBB (131)
