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(Since it was not found at the level of phytoene desaturase (PDS) in the cytosol [411], it is commonly accepted that -carotene, which is de novo synthesized in the plastid, undergoes oxidative modification in the ER to form AX [412])

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Additionally, after IOPs treatment, the protein expression of PI3K-p85, p-Akt (ser473), and glucose transporter protein 4 (GLUT4) was upregulated, suggesting that the anti-hyperglycemic mechanism of IOPs may involve the activation of PI3K and Akt phosphorylation, and GLUT4 transport in diabetic mice (Wang et al., 2017)

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Nevertheless, more studies are needed to describe the exact mechanism by which IGF-1 impacts and interacts with other factors and hormones in order to develop each component of MetS, T2D and its cardiovascular consequences