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Recent advances in FcR biology have identified four activating FcRs (FcRI, FcRIIa, FcRIIc and FcRIIIa) and one inhibitory FcR (FcRIIb) that have various Fc ligand specificities and cell-signalling motifs 10

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GH stimulates IGF-1 synthesis, which, in turn, affects GH production by the principle of negative feedback, inhibiting its synthesis (Figure 1)

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