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Histone acetylation, which is well characterized, is controlled by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs)

doi: 10.1038/cdd.2014.137 42 GalluzziL.VitaleI.AaronsonS

AAV4-mediated expression of IGF-1 and VEGF within cellular components of the ventricular system improves survival outcome in familial ALS mice

Its polyphenolic structure allows it to form non-covalent interactions with unfolded or partially folded proteins, targeting hydrophobic regions prone to aggregation