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GC is commonly treated with surgery (Mihmanli et al., 2016)

Wang D, Pajerowska-Mukhtar K, Culler AH, Dong X

Therapeutics that block RSL3-mediated GPX4 inactivation may provide a targeted approach to preserving antioxidant capacity in ARDS patients, reducing the extent of ferroptosis-driven lung damage ( 5.3 Iron chelators Iron overload exacerbates ferroptosis by fueling ROS production and lipid peroxidation, making iron chelation a viable therapeutic approach

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doi: 10.1038/s41419-023-05778-0 57 WangR.ShiD.PanX.RenA.JiangK

All these variants are associated not only with an increased risk of developing certain types of cancers (i.e., colorectal), but also with a greater susceptibility in developing severe toxicities (grade 3) during different chemotherapy regimens, including those containing taxane