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Mitochondrial dysfunction ( m -Dys)/altered bioenergetics The mitochondrion is the cellular powerhouse involved in oxidative phosphorylation (OXPHOS), ATP synthesis, and regulation of calcium (Ca 2+ ) signaling, redox homeostasis, lipid metabolism, cell differentiation, immune system, apoptosis, and cellular senescence (aging) 155,156

10.7759/cureus.18806 Carlos Salama, Emma Kaplan-Lewis, Richard Durrance, Linda Wong, Vasanthi Arumugam, Marilyn Fabbri

Neurology 74:691696 Koo DH, Ryu MH, Kim KM, Yang HK, Sawaki A, Hirota S, Zheng J, Zhang B, Tzen CY, Yeh CN, Nishida T, Shen L, Chen LT, Kang YK (2016) Asian consensus guidelines for the diagnosis and management of gastrointestinal stromal tumor

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In this study, tears of healthy individuals were collected using the clinically utilized Schirmer strips, separated by ultra-fast liquid chromatography (LC), and analysed by quadrupole time-of-flight tandem mass spectrometry (Q-TOF MS/MS)