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[15] Therefore, high doses of biotin (in the tens or hundreds of milligrams) are generally reserved for research settings or specific medical conditions like certain metabolic disorders or experimental therapies (e.g., very high-dose biotin has been investigated in multiple sclerosis)

Additionally, L-Carnitine supplementation led to increased production of lactate and pyruvate, enhanced activity of lactate dehydrogenase (LDH), and improved hexose transport, concluding that carnitine may play a crucial role in the intermediary metabolism of Sertoli cells by stimulating lipolytic and glycolytic processes

In women, OS is implicated in various reproductive disorders, including polycystic ovary syndrome, endometriosis, and premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, and poorer reproductive outcomes