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When connective tissue is weak or too stretchy, it can lead to joint instability, fragile skin, and a range of physical symptoms
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Neurology 17: 112116

doi: 10.1080/27697061.2023.2203235 19 AndreevaVAAssmannKEAdjibadeMLemogneCHercbergSGalanPet al

Hyperglycemia stimulates the proliferation of vascular smooth muscle cells and collagen synthesis, leading to fibrosis and hardening of the vascular wall, causing blood vessels to lose their elasticity, increasing vascular resistance and pressure, and inducing diabetic cardiovascular disease