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Similar randomized controlled trials looking at vitamin D supplementation in critically ill patients have demonstrated a survival benefit in select patients who were deficient on admission, but not in patients with normal levels at the time of admission [61]

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Circadian Rhythm Regulation and Melatonin Production Epithalon exerts significant regulatory effects on pineal gland function and circadian rhythm homeostasis, particularly in restoring age-related declines in melatonin synthesis

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