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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

Arch Biochem Biophys 704:108869

Date created: 2 January 2022

By filtering the top compounds with a LibDock score of more than 120 using Lipinskis rule of five (RO5) and Vebers rules (VR), its likely narrowed the list to compounds with a higher likelihood of being orally bioavailable and a better pharmacokinetic profile

10.1017/S1751731116001397 50

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