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3A and B, the balance of the TRX/TXNIP complex was disrupted in AS mice, indicated by increased TXNIP levels and decreased TRX levels

For over two centuries, a primary goal in protein research has been to understand how a linear polypeptide adopts its native 3D conformation, how folding can be measured experimentally, and how accurately this process can be predicted from sequence alone

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However, the emergence of drug-resistant strains in some individuals remains a major challenge, reducing overall cART efficacy and warranting the need for novel therapeutic strategies

emphasised the advancement of stimuli-responsive nanoplatforms such as pH-sensitive structures and redox-responsive polymers that enable protected and precise intracellular transport of CRISPR components [92]