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Bailey MM, Berkland CJ

Prior to each session, mice were habituated to the novel environment for at least 1 h

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This innovative delivery system not only addresses the challenges associated with the difficulty of mRNA crossing cell membranes and its susceptibility to nuclease degradation in vivo but also plays a crucial role in ensuring the stability and efficacy of mRNA vaccines

Through a paracrine mechanism, HSPA12A acts as a novel regulator of WAT browning, as evidenced by HSPA12A / mice exhibiting attenuated body temperature drop and enhanced thermogenic gene expression compared to WT mice after cold exposure, highlighting its crucial role in low-temperature energy metabolism (Cheng et al., 2019)