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2022 Sep;150(3):727-735.e6

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The NAD + /NADH redox pair modulates gene expression through redox-sensitive transcription factors [9], acts as a precursor of multiple NAD + -dependent enzymes involved in synaptic plasticity and neuronal stress resistance, and regulates crucial signaling pathways related to neuronal survival [10]

Yet, in the body, (1) -tocopherol is preferentially retained in the liver by the binding to -tocopherol transfer protein (-TTP), which incorporates -tocopherol into lipoproteins for delivery to extrahepatic tissues

FGF21 has originally been described as a fasting hormone that is upregulated in the liver via PPAR and partly regulates ketogenesis during starvation or KDs