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The phenyl groups of Phe260 and Phe649 undergo significant conformational changes upon SQ109 binding, and their phenyl ring rotates by 7 , forming a V-shaped structure, which matches with the adamantine group of SQ109

References Halliwell B, Gutteridge JMC: Free Radicals in Biology and Medicine

doi: 10.1016/j.berh.2024.101933 [DOI] [PubMed] [Google Scholar]

Considering c-MET in aspects of cell signaling network through cross-talking with EGFR, VEGFR-2 and other signaling molecules, it is necessary to develop antibodies that are able to inhibit simultaneously two signaling cascades to achieve maximal therapeutic activity [77, 119]

However, there are both opportunities and challenges for the clinical application of ferroptosis regulation

Activation of CREB enhances dendritic length and branching of granule neurons