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However, only post-treatment plasma acetylglycine showed a statistically significant increase from 2.42 0.97 to 3.06 1.50 mol/L (p = 0.002) (Supplementary Table 3)

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Glycogen is an evolutionary conserved antioxidant Because the de novo synthesis of cytoprotective enzymes is not necessary for glucose-mediated resistance to oxidants (Supplementary Table 1), we expected that the addition of glucose while challenging animals with an oxidant should be sufficient to protect them

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This level of metabolic resolution demonstrates the methods potential to uncover novel biological insights into toxicological mechanisms

For escitalopram, the frequencies were *1 (63.6%), *17 (1.2%), and loss-of-function alleles (35.2%)