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Given the limited evidence, selection among antidepressant classes in this population should be individualized based on the patients comorbidity profile, pain type, and risk factors for adverse effects

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Sleep and Biological Rhythms, 5 (2), 126-131

In addition, there is a particular susceptibility for demyelination in areas that are myelinated at older ages, a phenomenon referred to as neuropathologic retrogenesis [8, 12, 17, 66, 76]