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Obesity, polycystic ovary syndrome (PCOS), nulliparity, and late menopause are significant contributors, as they increase endogenous estrogen levels (50)

There is also evidence that sex hormones are important in SLE development (103)

Nanostructured drug delivery systems have attracted considerable attention as potential solutions (18), with nanotechnology offering transformative progress in the development of more efficient and targeted therapeutics (19)

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Her language and gross motor development were moderately delayed

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