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Although torcetrapib is a potent inhibitor of CETP, its use has been discontinued due to increased negative cardiovascular events and death rates in test subjects
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For example, -sitosterol has a saturated side chain at C24, unlike the branched chain in cholesterol
doi:10.1016/S0140-6736(23)00085-5 Liu JY, Xiong L, Stinear CM, Leung H, Leung TW, Wong KSL

Issa, MD, PhD Ms
Endocrinology and metabolism 306 , E13781387, (2014)
