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Convergent evidence from multiple classes of natural products indicates that modulation of this axis improves mitochondrial quality control, attenuates growth factor signalling, and supports chromatin stability [28,30,39]

PMID: 36909480

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KRAS and tumor microenvironment The tumor microenvironment encompasses the complex and dynamic surroundings of a tumor, including various cell types, extracellular matrix components, signaling molecules, and blood vessels [115, 116]

The relatively large sizes compared to small-molecule drugs and heterogeneous surface charges render most proteins impermeable to the cell-membrane
