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This work generates several possible hypotheses as to the metabolic adaptations accompanying cDDP-resistance and, although requiring biological demonstration, they pave the way to the use of metabolites as markers of resistance and as guidance to develop therapies to reverse resistance
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Indeed, brain copper in WD patients has been found to be 1015 higher than in brains of control individuals (Poujois et al., 2017)
T.HaroutunianV.et al
Another promising result was shown in a recent study using multiple rodent glaucoma models, in which the reactivation of CaMKII activity via the intravitreal injection of adeno-associated virus (AAV) vectors in diseased mice protects RGCs and preserves visual function and visually guided behavior [114]
