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This substitution promotes an abnormal salt bridge between the N-terminal and C-terminal domains, causing structural changes and altering the protein's folding and conformation

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Glucuronidation UDPglucuronosyltransferases (UGTs) belong among the key enzymes of metabolism of various exogenous as well as endogenous compounds

Role of Arrestin in Uncoupling of 2 Adrenoceptors from Heterotrimeric G Protein and Endocytosis It has been shown, in biochemical reconstitution studies, that increasingly purified fractions of ARK exhibited a reduced ability to attenuate 2 -AR-mediated signaling (Benovic et al., 1987a)

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