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Although none of these genes are DEGs in our mutants, the sam2/sam2 mutant cells do exhibit differentially expressed genes in a similar family of transporters, that export several drugs including cisplatin: we found downregulation of QDR2 (fold change of 0.48, p-value=0.0007), and upregulation of QDR3 (fold change of 1.76, p-value=0.00705) and ATR1 (fold change of 1.66, p-value=0.01755) (Fig 7)