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Description
This event is followed by the generation of ROS from the oxidation of FADH2 as induced by the demethylase, with consequent oxidation of nearby guanines (8-oxo-Gs) and recruitment of DNA repair enzymes (among which is APE1) that cause single-strand breaks in DNA and enable looping between the enhencer/promoter and the polyadenylation sites of the target genes, with productive transcription 140,141

10.3390/cancers13020313 74 MillenA

Studies have shown that when the kidney, heart and brain tissues are subjected to oxidizing agents in vitro, there is an increase in angiotensin-converting enzyme (ACE) activity

Badanjak K, Fixemer S, Smaji S, Skupin A, Grnewald A
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Riccomagno et al

doi: 10.1016/j.aquatox.2021.105897 81 LiuW
