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In agreement, mice deficient for Bach1, a negative regulator of the HO-1-inducing transcription factor Nrf2 (151), have dramatically higher HO-1 expression in the heart and display resistance to ischemia-reperfusion-induced myocardial injury (61, 152)

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Plasma curcumin levels were analyzed by reverse high-performance liquid chromatography to assess the pharmacokinetic parameters in vivo

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