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Additionally, use of bacteriostatic water is contraindicated in any patient with a known hypersensitivity to benzyl alcohol, as it could provoke an allergic reaction in such individuals

The exact cause is not fully understood, and experiences vary significantly from person to person

Gastrointestinal side effects (nausea, vomiting, diarrhea) occur in 3050% of tirzepatide users during dose titration and typically resolve within 48 weeks

1 Rasburicase is approved for managing hyperuricemia linked to chemotherapy in cancer patients

Endpoints frequently measured include the activity of alkaline phosphatase (ALP), an early marker of osteoblast differentiation, the expression of the master osteogenic transcription factor Runx2, and the deposition of a mineralized matrix, which can be visualized with Alizarin Red staining