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The first study was conducted using cerebrospinal fluid (CSF) from 5 people with early-onset RLS compared with 5 age- and sex-matched controls and demonstrated a significant upregulation of vitamin D binding protein (fold change[FC] = +2.3) in patients with RLS [38]

PDK phosphorylates the PDHA1, thereby inhibiting PDH activity and redirecting pyruvate away from the TCA cycle toward lactate production [73, 74]

Morone J, Lopes G, Morais J, Neves J, Vasconcelos V, Martins R (2022) Cosmetic application of cyanobacteria extracts with a sustainable vision to skincare: role in the antioxidant and antiaging process

Oncologist 9 (Suppl

IGF-1 increases cells sensitivity to insulin which has a glucose lowering effect
