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Previous studies have demonstrated that hydrogen gas can inhibit the formation of nitrotyrosine (Zhang et al., 2016), a detectable marker for the indirect measurement of ONOO (Wu et al., 2018), suggesting that hydrogen gas may exert its antioxidant effects by inhibiting ONOO

Activation of these energy-dissipating channels, in turn, influences the electrical excitability of the cardiac tissue

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For example, genetic polymorphisms in the genes encoding IGF-1 receptors or components of its signaling pathway may lead to variations in the effectiveness of IGF-1 therapy (Weroha and Haluska, 2008)