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The nine selected trials had created a diverse group, addressing various comparisons and outcomes, thereby resulting in several comparisons that contributed to each of our predefined outcomes

Of the various types of carnitine, L-carnitine and acetyl-L-carnitine (ALCAR) are the most popular and appear to be the most effective

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2,15,18 Lactic acidosis is a manifestation of poor tissue perfusion and can be aggravated by inhibition of mitochondrial calcium entry leading to decreased pyruvate dehydrogenase activity.18,19 Other effects are bowel infarction and ileus.2,20-22 Pulmonary oedema23-26 (both cardiogenic and non-cardiogenic) might be caused by excessive fluid resuscitation and precapillary vasodilatation, resulting in increased transcapillary pressure

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Thus, to our knowledge, palmitoyl-L-carnitine may worsen tau pathology through direct metabolic effects and inflammation-mediated kinase activation, highlighting its multifaceted role in neuroinflammation, oxidative stress, and kinase dysregulation associated with AD