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Genetic predisposition: Abnormal immune system response to infections (often respiratory or gastrointestinal) Risk Factors & Predisposing Factors: Age: Most common in late teens to 30s Gender: More common in males Ethnicity: Higher incidence in Asians and Caucasians Family history : Genetic predisposition is common

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FLT3 Inhibitors Upregulate CXCR4 and E-Selectin Ligands and CD44 Via ERK Suppression in AML Cells, and Blockade of CXCR4 and E-Selectin Signaling with GMI-1359 Overcomes AML Resistance to Quizartinib in Vitro and In Vivo

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