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In turn, this -keto acid is elongated by two methylene groups in a cyclical mechanism which involves two rounds of three successive transformations that take place in the chloroplast: (i) a condensation with acetyl-CoA, which is catalyzed by a methylthioalkyl malate synthase (MAM)

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Calabrese C, Pyle A, Griffin H, Coxhead J, Hussain R, Braund PS, Li L, Burgess A, Munroe PB, Little L, et al

According to an article about cobalamin deficiency in Tufts Universitys catnip newsletter, people with cobalamin deficiency also experience changes with intestinal permeability and absorptive function

doi: 10.1093/carcin/20.4.553

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