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Description
Arginine metabolic regulators such as spermidine have been shown to suppress M1 macrophage-associated cytokines while inducing M2 macrophage-related markers, significantly alleviating EAE symptoms, whereas Arg1 inhibitors can reverse these effects ( In other autoimmune diseases, amino acid metabolic reprogramming likewise participates in the formation of the inflammatory microenvironment by regulating macrophage polarization

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One study found that glutathione helps improve circulation and increase the amount of time these individuals can walk pain-free (10)

2a & Supplementary Fig
The reaction of ebselen with peroxynitrite

doi: 10.1016/j.amjms.2017.12.013
