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What cell-based assays are used to study NNMT inhibition and mitochondrial redox activity together

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Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue

Being membrane-permeable means its structured to pass directly through a cells outer wall to reach its target inside

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