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AKT/PKB signaling: navigating the network

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The FDA has approved the use of L-carnitine, either taken by mouth or given intravenously (by IV), for treating L-carnitine deficiency caused by certain genetic diseases or other disorders

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The common go-to treatment used in an emergent situation for ventricular tachycardia is lidocaine (a class Ib anti-arrhythmic), which can be administered IV as a bolus (as detailed in Table 1 ) and as a constant rate infusion if required for sustained ventricular tachycardia or during a crossover on to oral therapy

then, a decrease of acetyl-CoA/CoA ratio can relieve the inhibition of PDH thus affecting glucose oxidation
