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Consuming 20 mg/kg generally produces milder effects, while bumping the dose up to 50 mg/kg results in more pronounced effects and side effects

Through structural modification, structureactivity relationships could be inferred that the dihydrothiophene ring and methoxyl groups at C-16 and C-17 had a key role in the cytotoxicity of 181 , while the hydroxyl groups at C-1, C-11 and C-13 reduced the activity

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Future advancements may concentrate on stimuli-responsive nanocarriers, multifunctional nanoparticles for targeted antioxidant treatment, and biodegradable nanocarriers to reduce toxicity and enhance patient compliance

Recently, Wald et al (1998) estimated the risk of ischemic heart disease (angina pectoris or myocardial infarction) from eight retrospective studies and from their own positive prospective study, the British United Provident Association study, as a function of homocysteine level