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doi: 10.14336/AD.2024.0206 [DOI] [PMC free article] [PubMed] [Google Scholar] 145.Abdelgawad IY, Agostinucci K, Sadaf B, Grant MKO, Zordoky BN
Each iron atom in these clusters is coordinated by an additional amino acid, usually by the sulfur atom of cysteine
In addition, the KD is able to abate apoptosis of neurons (122)
It also characteristically affected the expression of enzymes superoxide dismutase, glutathione peroxidase and catalase, and influenced antioxidant activity
doi: 10.1038/s41467-021-21921-x 118 TaoSSWuGCZhangQZhangTPLengRXPanHFet al
This led to a clinical trial of laquinimod in primary progressive MS (ARPEGGIO trial), which is still ongoing (137)
