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The protein is not completely folded and glycosylated

Heres why: Ongoing Absorption Issues: Many people have conditions that impair their ability to absorb B12 from food or oral supplements, such as pernicious anemia or gastrointestinal disorders

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Then, mPEG 2000 DSPE was added to the formulations at 1, 2.5, and 5% (M18M29)