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Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin

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It is considered to be safe at therapeutic doses but it can induce a significant toxicity after overdose (Bessems and Vermeulen 2001)

DNMT2 has a minor maintenance role, and DNMT3L enhances DNMT3a/3b activity (Ting et al., 2006

Muradoglu, F

Os benefcios mais bem documentados nos estudos pr-clnicos incluem: acelerao da cicatrizao de tendes e ligamentos (com melhora das propriedades biomecnicas), proteo da mucosa gstrica contra AINEs e lcool (reduo de 78% da superfcie ulcerosa em modelos animais), estimulao da angiognese via VEGF, e efeitos neuroprotetores em modelos de leso cerebral