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Albeit some evidence of benefits has been observed in clinical outcomes of patients, precision nanoparticle design of N-acetylcysteine may allow for greater therapeutic efficacy

[DOI] [PubMed] [Google Scholar] Pandya JD, Readnower RD, Patel SP, Yonutas HM, Pauly JR, Goldstein GA, Rabchevsky AG, Sullivan PG (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI

Zhang Z, Su M, Jiang P, Wang X, Tong X, Wu G (2024) Unlocking apoptotic pathways: overcoming tumor resistance in CAR-T-cell therapy

This antitumorigenic effect is mediated through the activation of cyclin-dependent kinase inhibitors specifically p21 & p27, which disrupt the action of mitogenic growth factors such as insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF), while simultaneously enhancing the tumour-suppressive effects of transforming growth factor-beta (TGF-)