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[45] reported an epigenetic regulation system based on exosomal CRISPR intervention (RVG-CRISPRi-Exo), which consisted of exosome membranes encapsulating sgRNA targeting specific regions of the CpG island (CGI) in the murine SNCA gene, the dCas9-DNMT3A fusion protein, and RVG-Lamp2b, for PD treatment (Fig

10.1016/j.nbd.2006.10.007 [DOI] [PubMed] [Google Scholar] Hong S.-Y., Gil H.-W., Yang J.-O., Lee E.-Y., Kim H.-K., Kim S.-H., et al

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In the control group of rats, obstruction of the superior mesenteric vein was also observed, where peripheral and central thrombosis quickly appeared

Blood 116(21):1352, 2010

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