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The fact that nesfatin-1 co-localizes with neuroendocrine hormones, such as GHRH or somatostatin, may support this possibility

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Patients with systemic or local inflammatory conditions were excluded by 88% of trials

Nonetheless, targeting peripheral mGluRs has shown analgesic effectiveness, which suggest that spatiotemporal tuning of these receptors as a strategy with reduced off-target effects associated with systemic modulation of the glutamatergic system [162]

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Recently, the FDA granted accelerated approval for the use of a combination of pembrolizumab and lenvatinib in patients with advanced endometrial cancer who have experienced disease progression after systemic therapy