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It is not a drug, food additive, cosmetic, or therapeutic substance, and must not be used in humans or animals

Conversely, deletion of NE in obese mice fed a high-fat diet improved insulin sensitivity [34]

Post-transcriptional regulation of GCLM also occurs with 4-HNE treatment, which increased the stability of GCLM mRNA by an unknown mechanism that required de novo protein synthesis [122]

For instance, it has been recently observed that in prostate cancer patients, polymorphism in GSTM3-3 may contribute to resistance to hormonal therapy through oxidative stress 45

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