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MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

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The authors suggest that CuHIS treatment likely enhanced copper transport via residual CTR1 activity, or perhaps permeated cells via a CTR1-independent process resulting in the observed modest clinical improvement (Batzios et al., 2022)

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We will consider these individual requests received for changes to severity level designations as we continue our comprehensive CC/MCC analysis and will provide more detail in future rulemaking
