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The most important ones include PI3K/Akt for cell survival and proliferation, MAPK for fibroblast activity and collagen production, TGF-beta for extracellular matrix remodeling, VEGFR2 for angiogenesis, and NF-kB inhibition for resolving chronic inflammation that blocks healing

19 LiR.WangS.LiT.WuL.FangY.FengY.et al

99 (49), e23460
doi: 10.1016/S0140-6736(64)92227-5

The disability-adjusted life years (DALYs) associated with these NTDs in the USA are similar to those of HIV/AIDS, malaria, or tuberculosis in low- and middle-income countries

Zhang YT, Li Y, Sun CC, et al
